Sugi Predict

Sugi Predict / Compounds / SCHEMBL20567481

SCHEMBL20567481

SCHEMBL20567481

CCc1cc(Oc2ccc(NC(=O)C(N)CC)cn2)ccc1C#N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LTA4H P09960 1/20 0.42
▸ MAPT P10636 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ AR P10275 2/20 0.39
▸ AAK1 Q2M2I8 2/20 0.39
▸ PFKFB1 P16118 3/20 0.38
▸ NSD2 O96028 2/20 0.38
▸ AS3MT Q9HBK9 2/20 0.38
▸ PFKFB2 O60825 2/20 0.38
▸ PFKFB3 Q16875 2/20 0.38
▸ F11 P03951 2/20 0.38
▸ GFER P55789 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ CIT O14578 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ CASP3 P42574 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12594172 1.00 LTA4H (0.42) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL29437990 1.00 LTA4H (0.42) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL17188932 0.91 LTA4H (0.41) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL29437974 0.89 AAK1 (0.42) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL20568095 0.89 AAK1 (0.42) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL13720859 0.89 AAK1 (0.45) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL12594174 0.89 AAK1 (0.42) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL12595084 0.89 AAK1 (0.45) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL21980944 0.87 LTA4H (0.39) LTA4HMAPTALDH1A1ARAAK1
SCHEMBL13720827 0.87 LTA4H (0.39) LTA4HMAPTALDH1A1ARAAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11197859-B2 Hydantoin derivatives useful as Kv3 inhibitors AUTIFONY THERAPEUTICS LIMITED (GB) 2021-12-14 — — US disclosed
US-20200360379-A1 HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS GLAXOSMITHKLINE S.P.A. (IT) 2020-11-19 — — US disclosed
US-10632118-B2 Imidazolidinedione derivatives AUTIFONY THERAPEUTICS LIMITED (GB) 2020-04-28 — — US disclosed
US-20180338974-A1 IMIDAZOLIDINEDIONE DERIVATIVES AUTIFONY THERAPEUTICS LIMITED (GB) 2018-11-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180338974-A1 IMIDAZOLIDINEDIONE DERIVATIVES KCND3, KCNK3, KCNA3 LTA4H 4140/4885MAPT 3762/4885ALDH1A1 848/4885
US-10632118-B2 Imidazolidinedione derivatives KCND3, KCNK3, KCNA3 LTA4H 4140/4885MAPT 3762/4885ALDH1A1 848/4885
US-20200360379-A1 HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS KCNN3, KCND3, KCNA3 LTA4H 1839/4885MAPT 3926/4885ALDH1A1 1966/4885
US-11197859-B2 Hydantoin derivatives useful as Kv3 inhibitors KCNN3, KCND3, KCNA3 LTA4H 1839/4885MAPT 3926/4885ALDH1A1 1966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.