Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ESRRG | P62508 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31203036 | 0.83 | HTT (0.67) | ALDH1A1MAPTLMNAHTTPOLB | |
| SCHEMBL26757977 | 0.81 | HTT (0.56) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL20568584 | 0.80 | SMN1; SMN2 (0.52) | ALDH1A1KMT2ALMNAHTTPOLB | |
| SCHEMBL6111089 | 0.80 | MCHR1 (0.53) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL7460757 | 0.79 | CYP1A2 (0.64) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL5713303 | 0.79 | HTT (0.54) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL18770223 | 0.78 | HTT (0.53) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL7476700 | 0.77 | HTT (0.49) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL16045437 | 0.77 | L3MBTL1 (0.60) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL17687389 | 0.77 | GAA (0.55) | ALDH1A1MAPTKMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | disclosed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | disclosed |