SCHEMBL20567987

SCHEMBL20567987

CCOC(=O)c1c(Cl)c2cc([N+](=O)[O-])ccc2n(C)c1=O

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.61
TP53 P04637 1/20 0.54
ALDH1A1 P00352 2/20 0.50
KDM4E B2RXH2 1/20 0.50
LMNA P02545 1/20 0.50
AR P10275 1/20 0.50
PKM P14618 1/20 0.48
ELANE P08246 4/20 0.48
NPC1 O15118 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
F2 P00734 3/20 0.46
PLAU P00749 3/20 0.46
CTRB1 P17538 3/20 0.46
MAPK1 P28482 1/20 0.46
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
PDE4B Q07343 1/20 0.43
PDE4D Q08499 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29712306 1.00 MAPT (0.61) MAPTTP53ALDH1A1KDM4ELMNA
SCHEMBL21462498 0.88 ALDH1A1 (0.63) MAPTTP53ALDH1A1KDM4ELMNA
SCHEMBL29712314 0.88 ALDH1A1 (0.63) MAPTTP53ALDH1A1KDM4ELMNA
SCHEMBL26925237 0.86 MAPT (0.50) MAPTTP53ALDH1A1LMNAAR
SCHEMBL30732053 0.86 MAPT (0.50) MAPTTP53ALDH1A1LMNAAR
SCHEMBL20267468 0.85 MAPT (0.62) MAPTTP53ALDH1A1KDM4ELMNA
SCHEMBL30415002 0.85 MAPT (0.62) MAPTTP53ALDH1A1KDM4ELMNA
SCHEMBL4680172 0.85 MAPT (0.75) MAPTTP53LMNAARPKM
SCHEMBL11313274 0.83 ALDH1A1 (0.60) ALDH1A1KDM4ELMNAL3MBTL1MEN1
SCHEMBL31434014 0.81 MAPT (0.62) MAPTTP53ALDH1A1KDM4EAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4729127-A2 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2026-04-22 EP claimed
US-20260042776-A1 BCL6 INHIBITORS CANCER RESEARCH TECH LTD (GB) 2026-02-12 US claimed
EP-4729127-A2 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2026-04-22 EP disclosed
US-20260042776-A1 BCL6 INHIBITORS CANCER RESEARCH TECH LTD (GB) 2026-02-12 US disclosed
US-12528826-B2 [1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2026-01-20 US disclosed
US-12486285-B2 BCL6 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2025-12-02 US disclosed
US-20250074890-A1 CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-03-06 US disclosed
US-20240217987-A1 INHIBITOR COMPOUNDS THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2024-07-04 US disclosed
US-20240217987-A1 INHIBITOR COMPOUNDS THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2024-07-04 US disclosed
EP-4380919-A1 CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS Dana-Farber Cancer Institute, Inc. (US) 2024-06-12 EP disclosed
EP-3630749-B9 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-05-29 EP disclosed
US-20210163497-A1 BCL6 INHIBITORS THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-06-03 US disclosed
US-20210163497-A1 BCL6 INHIBITORS THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-06-03 US disclosed
WO-2021074620-A1 [1,4]OXAZEPINO[2,3-C]QUI NOLI NONE DERIVATIVES AS BLC6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-04-22 WO disclosed
EP-3774817-A1 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2021-02-17 EP disclosed
CN-112334475-A BCL6 inhibitor 癌症研究技术有限公司 2021-02-05 CN disclosed
EP-3630749-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2020-04-08 EP disclosed
WO-2019197842-A1 BCL6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2019-10-17 WO disclosed
WO-2019197842-A1 BCL6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2019-10-17 WO disclosed
WO-2018215798-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2018-11-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12528826-B2 [1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors BCL6, BCL6B, BCL3 MAPT 4406/4885TP53 109/4885ALDH1A1 1668/4885
US-20210163497-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL3 MAPT 3855/4885TP53 236/4885ALDH1A1 2602/4885
US-20250074890-A1 CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS BCL6, BCL6B, BCOR MAPT 3448/4885TP53 50/4885ALDH1A1 2828/4885
US-12486285-B2 BCL6 inhibitors BCL6, BCL6B, BCL3 MAPT 3855/4885TP53 236/4885ALDH1A1 2602/4885
US-20240217987-A1 INHIBITOR COMPOUNDS BCL6, BCL6B, BCL3 MAPT 2384/4885TP53 62/4885ALDH1A1 2960/4885
US-20260042776-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL9 MAPT 3429/4885TP53 462/4885ALDH1A1 3510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.