Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | HCK | P08631 | 2/20 | 0.61 |
| ▸ | NR2C2 | P49116 | 2/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.56 |
| ▸ | FES | P07332 | 2/20 | 0.56 |
| ▸ | FER | P16591 | 2/20 | 0.56 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | GCK | P35557 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389535 | 0.90 | HTT (0.71) | HTTMAPK1ATMHCKNR2C2 | |
| SCHEMBL20568437 | 0.90 | EPHA2 (0.61) | HTTMAPK1ATMHCKNR2C2 | |
| SCHEMBL2226481 | 0.86 | HTT (0.68) | HTTMAPK1ATMHCKNR2C2 | |
| SCHEMBL20569514 | 0.85 | EPHA2 (0.57) | HTTMAPK1ATMHCKNR2C2 | |
| SCHEMBL26215628 | 0.85 | HTT (0.58) | HTTMAPK1ATMHCKNR2C2 | |
| SCHEMBL1420251 | 0.85 | EPHA2 (0.62) | HTTMAPK1ATMEPHA2KIT | |
| SCHEMBL28054362 | 0.84 | HTT (0.65) | HTTMAPK1ATMHCKNR2C2 | |
| SCHEMBL30309801 | 0.83 | KIT (0.69) | HTTMAPK1ATMHCKNR2C2 | |
| SCHEMBL26680109 | 0.83 | KIT (0.69) | HTTMAPK1ATMHCKNR2C2 | |
| SCHEMBL4260023 | 0.82 | HTT (0.66) | HTTMAPK1ATMHCKNR2C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | disclosed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | disclosed |