SCHEMBL20568614

SCHEMBL20568614

NC(=O)c1nccc(N)c1-c1ccc2c(c1)C=CCN2

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 1/20 0.32
MKNK2 Q9HBH9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20568616 0.83 BTK (0.32) MKNK1MKNK2
SCHEMBL20568817 0.70 PRKACA (0.36)
SCHEMBL26685289 0.69 BRAF (0.32)
SCHEMBL30688546 0.69 BRAF (0.32)
SCHEMBL23067310 0.69 MAP2K3 (0.50)
SCHEMBL22418394 0.66 ADORA3 (0.36)
SCHEMBL20568277 0.65 ABL1 (0.34)
Hydrochloric Acid SCHEMBL28292048 0.65 ADORA3 (0.35)
SCHEMBL15882337 0.64 MKNK2 (0.39) MKNK1MKNK2
SCHEMBL18917079 0.61 MAP2K3 (0.44) MKNK1MKNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3630749-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2020-04-08 EP disclosed
WO-2018215798-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2018-11-29 WO disclosed