Sugi Predict

Sugi Predict / Compounds / SCHEMBL20569282

SCHEMBL20569282

SCHEMBL20569282

Cc1ncc([N+](=O)[O-])cc1C(F)(F)F

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.65
▸ MEN1 O00255 3/20 0.40
▸ KMT2A Q03164 3/20 0.40
▸ HTT P42858 2/20 0.40
▸ MAPT P10636 2/20 0.40
▸ PKM P14618 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ IDO1 P14902 1/20 0.40
▸ GALR3 O60755 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ LMNA P02545 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.38
▸ PDE7A Q13946 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ HSP90AA1 P07900 1/20 0.38
▸ CXCR5 P32302 1/20 0.38
▸ APLNR P35414 1/20 0.38
▸ CCR6 P51684 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29455943 1.00 ALDH1A1 (0.65) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL26878892 0.81 ALDH1A1 (0.62) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL1278657 0.79 ALDH1A1 (0.60) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL31053163 0.79 ALDH1A1 (0.60) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL30517122 0.79 ALDH1A1 (0.60) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL25299377 0.79 ALDH1A1 (0.60) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL3650139 0.79 ALDH1A1 (0.60) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL909398 0.79 ALDH1A1 (0.60) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL909437 0.79 ALDH1A1 (0.60) ALDH1A1MEN1KMT2AHTTMAPT
SCHEMBL30517139 0.79 ALDH1A1 (0.60) ALDH1A1MEN1KMT2AHTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078117-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS INC (US) 2026-03-19 — — US disclosed
US-12304907-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-05-20 — — US disclosed
US-12264154-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-04-01 — — US disclosed
US-20240279219-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-08-22 — — US disclosed
US-20240228478-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-07-11 — — US disclosed
US-11999727-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2024-06-04 — — US disclosed
CN-116568677-A piperidin-1-yl-N-pyridin-3-yl-2-oxoacetamide derivatives useful for the treatment of MTAP deficiency and/or MTA accumulating cancers 探戈医药股份有限公司 2023-08-08 — — CN disclosed
EP-4188920-A1 PIPERIDIN-1-YL-N-PYRYDINE-3-YL-2-OXOACETAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MTA-ACCUMULATING CANCERS Tango Therapeutics, Inc. (US) 2023-06-07 — — EP disclosed
US-20230113778-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2023-04-13 — — US disclosed
US-11492350-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2022-11-08 — — US disclosed
US-20220127256-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2022-04-28 — — US disclosed
CN-109232399-B Synthetic method of 5-bromo-2-methyl-3- (trifluoromethyl) pyridine 上海毕得医药科技股份有限公司 2022-02-15 — — CN disclosed
CN-109232399-B Synthetic method of 5-bromo-2-methyl-3- (trifluoromethyl) pyridine 上海毕得医药科技股份有限公司 2022-02-15 — — CN disclosed
WO-2022026892-A1 PIPERIDIN-1- YL-N-PYRYDI NE-3-YL-2-OXOACET AM IDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MT A-ACCUMULATING CANCERS TANGO THERAPEUTICS, INC. (US) 2022-02-03 — — WO disclosed
CN-112601752-A Novel inhibitors of MAP4K1 伊克诺斯科学公司 2021-04-02 — — CN disclosed
EP-3630778-A1 NOVEL INHIBITORS OF MAP4K1 Ichnos Sciences SA (CH) 2020-04-08 — — EP disclosed
CN-109232399-A A kind of synthetic method of bromo- 2- methyl -3- (trifluoromethyl) pyridine of 5- 上海毕得医药科技有限公司 2019-01-18 — — CN disclosed
CN-109232399-A A kind of synthetic method of bromo- 2- methyl -3- (trifluoromethyl) pyridine of 5- 上海毕得医药科技有限公司 2019-01-18 — — CN disclosed
WO-2018215668-A1 NOVEL INHIBITORS OF MAP4K1 GLENMARK PHARMACEUTICALS S.A. (CH) 2018-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11999727-B2 Compounds and methods of use F12, C1R, ABCG2 ALDH1A1 128/4885MEN1 142/4885KMT2A 4008/4885
US-20240279219-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 ALDH1A1 128/4885MEN1 142/4885KMT2A 4008/4885
US-11492350-B2 Compounds and methods of use F12, C1R, ABCG2 ALDH1A1 128/4885MEN1 142/4885KMT2A 4008/4885
US-20230113778-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 ALDH1A1 128/4885MEN1 142/4885KMT2A 4008/4885
US-12264154-B2 Compounds and methods of use F12, C1R, ABCG2 ALDH1A1 128/4885MEN1 142/4885KMT2A 4008/4885
US-12304907-B2 Compounds and methods of use F12, C1R, ABCG2 ALDH1A1 128/4885MEN1 142/4885KMT2A 4008/4885
US-20220127256-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 ALDH1A1 128/4885MEN1 142/4885KMT2A 4008/4885
US-20240228478-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 ALDH1A1 128/4885MEN1 142/4885KMT2A 4008/4885
US-20260078117-A1 COMPOUNDS AND METHODS OF USE NR3C2, ADRA1A, CNR1 ALDH1A1 100/4885MEN1 1978/4885KMT2A 3362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.