Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.55 |
| ▸ | ARG1 | P05089 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20569246 | 0.95 | TLR8 (0.53) | TLR8ARG1KCNH2FLT1KDR | |
| SCHEMBL6639388 | 0.89 | TLR8 (0.47) | TLR8ARG1KCNH2FLT1KDR | |
| SCHEMBL7508654 | 0.80 | MEN1 (0.51) | TLR8KCNH2MEN1ALDH1A1CYP1A2 | |
| SCHEMBL20569455 | 0.78 | KCNH2 (0.49) | TLR8KCNH2 | |
| SCHEMBL20570073 | 0.77 | FLT1 (0.52) | FLT1KDR | |
| SCHEMBL27637305 | 0.77 | TLR8 (0.70) | TLR8ARG1KCNH2ALDH1A1KMT2A | |
| SCHEMBL20570534 | 0.76 | KCNH2 (0.39) | KCNH2FLT1KDR | |
| SCHEMBL20570323 | 0.75 | KCNH2 (0.49) | KCNH2FLT1KDRMEN1ALDH1A1 | |
| SCHEMBL27658200 | 0.75 | TLR8 (0.67) | TLR8ARG1KCNH2ALDH1A1KMT2A | |
| SCHEMBL20570174 | 0.74 | KCNH2 (0.40) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018216823-A1 | ALPHA-AMINO AMIDE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2018-11-29 | — | — | WO | disclosed |