SCHEMBL20569866

SCHEMBL20569866

C[C@H](O)[C@@H](Nc1cccc(OC(F)(F)F)c1)C(N)=O

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
ALDH1A1 P00352 1/20 0.44
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
HTT P42858 1/20 0.44
LMNA P02545 1/20 0.44
POLB P06746 1/20 0.44
P2RX1 P51575 1/20 0.44
EPHX2 P34913 1/20 0.42
KCNK3 O14649 2/20 0.41
KCNK9 Q9NPC2 2/20 0.41
HDAC8 Q9BY41 1/20 0.41
SLC22A12 Q96S37 1/20 0.40
EPHX1 P07099 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20569885 0.83 POLB (0.41) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL734815 0.79 NPC1 (0.49) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL734814 0.79 NPC1 (0.49) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL3459396 0.77 NPC1 (0.48) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL21571874 0.77 NPC1 (0.46) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL20569865 0.77 NPC1 (0.51) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL20569868 0.77 NPC1 (0.51) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL27994043 0.76 NPC1 (0.47) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL167677 0.75 ALDH1A1 (0.63) NPC1RAB9AALDH1A1GAAMAPT
SCHEMBL19538915 0.74 MTNR1B (0.57) NPC1RAB9AALDH1A1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018216823-A1 ALPHA-AMINO AMIDE DERIVATIVES TAISHO PHARMACEUTICAL CO., LTD. (JP) 2018-11-29 WO disclosed