Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.85 |
| ▸ | TP53 | P04637 | 3/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | CCR2 | P41597 | 1/20 | 0.75 |
| ▸ | CCR5 | P51681 | 1/20 | 0.75 |
| ▸ | IDH2 | P48735 | 4/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | CTSC | P53634 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30754779 | 1.00 | MAPT (0.85) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL22542652 | 0.94 | TP53 (0.85) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL26035087 | 0.92 | MAPT (0.84) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL3057044 | 0.92 | MAPT (0.73) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL26034850 | 0.90 | MAPT (0.71) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL22542936 | 0.89 | MAPT (0.72) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL30754716 | 0.89 | MAPT (0.72) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL21499963 | 0.87 | MAPT (0.67) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL26035431 | 0.87 | MAPT (0.66) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL26035027 | 0.85 | MAPT (0.64) | MAPTTP53SMN1; SMN2POLBCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11896591-B2 | Compositions and methods for preparing and using mitochondrial uncouplers | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2024-02-13 | — | — | US | disclosed |
| WO-2023159248-A1 | RE-SENSITIZING MULTIDRUG-RESISTANT (MDR) GRAM-NEGATIVE BACTERIA TO COLISTIN USING IONOPHORES | THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) | 2023-08-24 | — | — | WO | disclosed |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) | 2020-10-15 | — | — | US | disclosed |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) | 2020-10-15 | — | — | US | disclosed |
| EP-3630115-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | University Of Virginia Patent Foundation (US) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018217757-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11896591-B2 | Compositions and methods for preparing and using mitochondrial uncouplers | ACAD9, GPR119, NDUFAF1 | MAPT 3834/4885TP53 3537/4885SMN1; SMN2 334/4885 |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | ACAD9, GPR119, NDUFAF1 | MAPT 3834/4885TP53 3537/4885SMN1; SMN2 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.