Sugi Predict

Sugi Predict / Targets / NDUFAF1

NDUFAF1

Complex I intermediate-associated protein 30, · Q9Y375 · NDUFAF1 on Sugi Atlas →

390 patent compounds predicted against NDUFAF1, 218 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15258558 SCHEMBL15258558 0.76 8/20
R-(+)-Marmin R-(+)-Marmin (SCHEMBL27804600) 0.83 7/20
R-(+)-Marmin R-(+)-Marmin (SCHEMBL29353819) 0.83 7/20
R-(+)-Marmin R-(+)-Marmin (SCHEMBL29625637) 0.83 7/20
SCHEMBL12362713 SCHEMBL12362713 0.77 7/20
SCHEMBL15080621 SCHEMBL15080621 0.77 7/20
SCHEMBL12362702 SCHEMBL12362702 0.73 7/20
SCHEMBL31179835 SCHEMBL31179835 0.59 7/20
SCHEMBL31000416 SCHEMBL31000416 0.78 6/20
SCHEMBL13973668 SCHEMBL13973668 0.47 6/20
SCHEMBL16316892 SCHEMBL16316892 0.47 6/20
Auraptene Auraptene (SCHEMBL2535029) 1.00 5/20
Auraptene Auraptene (SCHEMBL2535034) 1.00 5/20
SCHEMBL29999425 SCHEMBL29999425 0.83 5/20
SCHEMBL24700226 SCHEMBL24700226 0.81 5/20
SCHEMBL25269817 SCHEMBL25269817 0.68 5/20
SCHEMBL14437596 SCHEMBL14437596 0.57 5/20
SCHEMBL14437626 SCHEMBL14437626 0.57 5/20
SCHEMBL14515244 SCHEMBL14515244 0.57 5/20
SCHEMBL11456503 SCHEMBL11456503 0.71 4/20

Clinical trials — most relevant to NDUFAF1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome PHASE2RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Nicotinamide Riboside in LVAD Recipients EARLY_PHASE1COMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
The Natural History of Mitochondrial Diseases nanRECRUITING
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
Survey on Supplement Use in Mitochondrial Disease nanCOMPLETED
Calf Muscle Strength in Mitochondrial Diseases nanCOMPLETED
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS nanRECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Human Mitochondrial Stress-driven Obesity Resistance nanCOMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Diagnostic Odyssey Survey 2 nanCOMPLETED
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants nanRECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NDUFAF1 binder may also engage these)

ProteinNameSimilarity
Q0MQ82 — 1.000 Q0MQ82 →
Q0MQ83 — 1.000 Q0MQ83 →
Q0MQ84 — 1.000 Q0MQ84 →
Q9CWX2 — 0.999 Q9CWX2 →
Q9VAI1 — 0.981 Q9VAI1 →
Q18726 — 0.980 Q18726 →
Q5SNQ7 — 0.980 Q5SNQ7 →
Q92503 — 0.980 Q92503 →
Q3U213 — 0.978 Q3U213 →
Q9JHD2 — 0.977 Q9JHD2 →
Q8C0M0 — 0.977 Q8C0M0 →
Q6PJI9 — 0.977 Q6PJI9 →
Q5XHF8 — 0.977 Q5XHF8 →
Q3UFY8 — 0.976 Q3UFY8 →
Q80U87 — 0.976 Q80U87 →
KAT2A Histone acetyltransferase KAT2A 0.976 landscape →
Q80WQ6 — 0.976 Q80WQ6 →
Q96JX3 — 0.976 Q96JX3 →
Q8K1N1 — 0.976 Q8K1N1 →
Q6GMF8 — 0.976 Q6GMF8 →
Q8VIJ5 — 0.976 Q8VIJ5 →
B5DE73 — 0.976 B5DE73 →
Q812E4 — 0.976 Q812E4 →
Q8C5W4 — 0.976 Q8C5W4 →
Q8VDY4 — 0.976 Q8VDY4 →
Q8GT06 — 0.976 Q8GT06 →
Q5XTS1 — 0.975 Q5XTS1 →
Q6P5D8 — 0.975 Q6P5D8 →
Q8R4Z9 — 0.975 Q8R4Z9 →
Q6PFW1 — 0.975 Q6PFW1 →