Famciclovir

Famciclovir

SCHEMBL20570567

CC(=O)OCC(CCn1cnc2cnc(N)nc21)COC(C)=O.CC(C)[C@H](N)C(=O)OCCOCn1cnc2c(=O)[nH]c(N)nc21.Nc1nc(=O)c2ncn(CCC(CO)CO)c2[nH]1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
HBB P68871 2/20 0.58
MAPK1 P28482 1/20 0.58
HSD17B10 Q99714 2/20 0.52
ALDH1A1 P00352 2/20 0.52
KDM4E B2RXH2 1/20 0.52
HPGD P15428 1/20 0.52
ADRA1A P35348 1/20 0.52
RXFP1 Q9HBX9 1/20 0.52
PDE3A Q14432 1/20 0.49
PNP P00491 7/20 0.42
TSHR P16473 2/20 0.42
BLM P54132 2/20 0.42
USP2 O75604 1/20 0.42
EDNRA P25101 1/20 0.42
HTR2A P28223 1/20 0.42
RECQL P46063 1/20 0.42
HPRT1 P00492 4/20 0.39
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Famciclovir SCHEMBL18526964 0.99 MEN1 (0.58) MEN1KMT2AHBBMAPK1HSD17B10
Valacyclovir SCHEMBL20570801 0.89 MEN1 (0.75) MEN1KMT2AHBBMAPK1HSD17B10
Famciclovir SCHEMBL384993 0.86 ALDH1A1 (0.69) MEN1KMT2AHSD17B10ALDH1A1KDM4E
Famciclovir SCHEMBL4166714 0.86 HSD17B10 (0.66) MEN1KMT2AHBBMAPK1HSD17B10
Valganciclovir SCHEMBL17219665 0.84 ALDH1A1 (0.57) MEN1KMT2AHBBMAPK1HSD17B10
Famciclovir SCHEMBL9066419 0.84 HSD17B10 (0.54) MEN1KMT2AHBBMAPK1HSD17B10
Famciclovir SCHEMBL15228828 0.82 ALDH1A1 (0.65) MEN1KMT2AHSD17B10ALDH1A1KDM4E
Valganciclovir SCHEMBL336814 0.79 PDE3A (0.78) MEN1KMT2AHBBMAPK1HSD17B10
Penciclovir SCHEMBL5171433 0.78 PNP (0.70) MEN1KMT2AHBBMAPK1HSD17B10
Valacyclovir SCHEMBL13575743 0.77 MEN1 (1.00) MEN1KMT2AHBBMAPK1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200215131-A1 METHODS FOR TREATING AND PREVENTING DISEASES Tets, Viktor Veniaminovich (US) 2020-07-09 US disclosed
EP-3634442-A1 METHODS FOR TREATING AND PREVENTING DISEASES Tets, Viktor, Veniaminovich (US) 2020-04-15 EP disclosed
WO-2018217351-A1 METHODS FOR TREATING AND PREVENTING DISEASES TETS VIKTOR VENIAMINOVICH (US) 2018-11-29 WO disclosed