Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.40 |
| ▸ | PADI4 | Q9UM07 | 4/20 | 0.38 |
| ▸ | DHODH | Q02127 | 8/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157057 | 0.85 | NR4A2 (0.47) | DHODHBRD4KDM4E | |
| SCHEMBL28757158 | 0.75 | DAO (0.52) | PADI4DHODH | |
| SCHEMBL4237180 | 0.74 | PADI4 (0.36) | PADI4DHODHHCAR2 | |
| SCHEMBL21819026 | 0.71 | AURKA (0.45) | DHODHBRD4 | |
| SCHEMBL8468860 | 0.71 | TYMS (0.33) | — | |
| SCHEMBL5857601 | 0.71 | KEAP1 (0.50) | KDM4E | |
| SCHEMBL2814713 | 0.69 | AXL (0.47) | KDM4EASPHKDM8 | |
| SCHEMBL8329308 | 0.69 | MAP4K1 (0.37) | — | |
| SCHEMBL8329311 | 0.69 | CYP3A4 (0.41) | AGBL2KDM4E | |
| SCHEMBL25169884 | 0.68 | PTGS1 (0.55) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513110-B1 | 1,7-DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER | HOFFMANN LA ROCHE (CH) | 2018-12-05 | — | — | EP | disclosed |