Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8468860 | 0.71 | TYMS (0.33) | SNCA | |
| SCHEMBL22761967 | 0.69 | MAP4K1 (0.34) | MAP4K1 | |
| SCHEMBL20573191 | 0.69 | AGBL2 (0.40) | — | |
| SCHEMBL8329311 | 0.69 | CYP3A4 (0.41) | MAP4K1SNCA | |
| SCHEMBL2157057 | 0.67 | NR4A2 (0.47) | — | |
| SCHEMBL8330645 | 0.67 | MAP4K1 (0.33) | MAP4K1SNCA | |
| SCHEMBL23101646 | 0.67 | MAP4K1 (0.46) | MAP4K1 | |
| SCHEMBL24565957 | 0.65 | PDK2 (0.38) | — | |
| SCHEMBL14070089 | 0.62 | GRM4 (0.39) | — | |
| SCHEMBL30806243 | 0.62 | GRM4 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0580616-A1 | NEW ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992017477-A1 | NEW ACTIVE COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1992-10-15 | — | — | WO | disclosed |