Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.78 |
| ▸ | RAF1 | P04049 | 10/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.76 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.76 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.76 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.76 |
| ▸ | KDR | P35968 | 6/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.76 |
| ▸ | ARAF | P10398 | 2/20 | 0.76 |
| ▸ | BRAF | P15056 | 2/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20573690 | 0.94 | RAF1 (0.77) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL22473654 | 0.89 | RAF1 (0.82) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL19677974 | 0.88 | RAF1 (0.68) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL3707691 | 0.88 | RAF1 (0.83) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL21973628 | 0.88 | RAF1 (0.82) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL22879109 | 0.88 | RAF1 (0.67) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL8147438 | 0.87 | HDAC3 (0.98) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL20386908 | 0.87 | GSK3B (0.80) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL20574017 | 0.87 | RAF1 (0.70) | GSK3BRAF1HDAC3HDAC4HDAC1 | |
| SCHEMBL20573404 | 0.87 | RAF1 (0.70) | GSK3BRAF1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-09-29 | — | — | US | disclosed |
| US-10787443-B2 | RAF-degrading conjugate compounds | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-09-29 | — | — | US | disclosed |
| CN-110545853-A | RAF degrading coupled compounds | QUARTZ THERAPEUTICS INC | 2019-12-06 | — | — | CN | disclosed |
| US-20180346457-A1 | RAF-DEGRADING CONJUGATE COMPOUNDS | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346457-A1 | RAF-DEGRADING CONJUGATE COMPOUNDS | BRAF, RAF1, ARAF | GSK3B 2066/4885RAF1 2/4885HDAC3 2276/4885 |
| US-10787443-B2 | RAF-degrading conjugate compounds | BRAF, RAF1, ARAF | GSK3B 2066/4885RAF1 2/4885HDAC3 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.