Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14910704 | 0.87 | PDE4D (0.67) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL10238578 | 0.86 | MAPT (0.46) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL2056467 | 0.86 | SMN1; SMN2 (0.57) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL14911037 | 0.86 | HDAC3 (0.52) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL10200469 | 0.86 | MAPT (0.46) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL2090174 | 0.83 | MAPT (0.47) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL1662318 | 0.81 | MAPT (0.68) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL27776660 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL167088 | 0.79 | MAPT (0.67) | MAPTMEN1KMT2AGAAKDM4E | |
| SCHEMBL14910131 | 0.78 | NPC1 (0.51) | MAPTMEN1KMT2AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738033-B2 | Trk inhibition | NANTBIO, INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-20180346451-A1 | TRK INHIBITION | NANTBIO, INC. | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346451-A1 | TRK INHIBITION | NGFR, NGF, NTRK1 | PDE4A 3083/4885PDE4B 3395/4885PDE4C 3405/4885 |
| US-10738033-B2 | Trk inhibition | NGF, NGFR, NTRK2 | PDE4A 2858/4885PDE4B 2875/4885PDE4C 3027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.