Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.67 |
| ▸ | PDE4A | P27815 | 4/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20575703 | 0.87 | PDE4A (0.60) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL14911053 | 0.83 | PDE4A (0.46) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL14910816 | 0.82 | LMNA (0.45) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL2056467 | 0.80 | SMN1; SMN2 (0.57) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| Zardaverine SCHEMBL15263214 | 0.80 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| Zardaverine SCHEMBL13334 | 0.80 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| Zardaverine SCHEMBL29388700 | 0.80 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL29892342 | 0.78 | PDE4A (0.69) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL19283081 | 0.78 | PDE4A (0.69) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL10200469 | 0.77 | MAPT (0.46) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118067-B1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SIENA BIOTECH SPA (IT) | 2013-05-08 | — | — | EP | disclosed |