Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18707215 | 0.89 | KDR (0.55) | KDRALDH1A1MAPTHTTMEN1 | |
| SCHEMBL22842949 | 0.88 | KDR (0.52) | KDRALDH1A1MAPTHTTMEN1 | |
| SCHEMBL4897162 | 0.88 | KDR (0.54) | KDRALDH1A1MAPTHTTMEN1 | |
| SCHEMBL15876465 | 0.88 | LTA4H (0.54) | KDRMEN1KMT2AKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL20574681 | 0.87 | ALDH1A1 (0.53) | KDRALDH1A1MAPTHTTMEN1 | |
| Hydrochloric Acid SCHEMBL228093 | 0.86 | LTA4H (0.53) | KDRMEN1KMT2AKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL224259 | 0.86 | LTA4H (0.53) | KDRMEN1KMT2AKDM4ETSHR | |
| SCHEMBL5562205 | 0.84 | SMN1; SMN2 (0.55) | KDRALDH1A1MAPTHTTMEN1 | |
| SCHEMBL18707352 | 0.80 | SMN1; SMN2 (0.52) | KDRALDH1A1MAPTHTTMEN1 | |
| SCHEMBL990939 | 0.79 | GAA (0.71) | ALDH1A1MAPTKMT2AKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630100-A1 | FUSED BICYCLIC COMPOUNDS | Akarna Therapeutics, Ltd. (GB) | 2020-04-08 | — | — | EP | claimed |
| WO-2018222876-A1 | FUSED BICYCLIC COMPOUNDS | AKARNA THERAPEUTICS, LTD. (GB) | 2018-12-06 | — | — | WO | claimed |
| US-20200407364-A1 | FUSED BICYCLIC COMPOUNDS | AKARNA THERAPEUTICS LTD (GB) | 2020-12-31 | — | — | US | disclosed |
| EP-3630100-A1 | FUSED BICYCLIC COMPOUNDS | Akarna Therapeutics, Ltd. (GB) | 2020-04-08 | — | — | EP | disclosed |
| US-20180346473-A1 | FUSED BICYCLIC COMPOUNDS | AKARNA THERAPEUTICS, LTD. (TW) | 2018-12-06 | — | — | US | disclosed |
| WO-2018222876-A1 | FUSED BICYCLIC COMPOUNDS | AKARNA THERAPEUTICS, LTD. (GB) | 2018-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346473-A1 | FUSED BICYCLIC COMPOUNDS | BICRA, PAICS, NDC1 | KDR 2570/4885ALDH1A1 3163/4885MAPT 2404/4885 |
| US-20200407364-A1 | FUSED BICYCLIC COMPOUNDS | BICRA, PAICS, NDC1 | KDR 2570/4885ALDH1A1 3163/4885MAPT 2404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.