Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluoromethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705904 | 0.95 | GAA (0.62) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL5068661 | 0.95 | GAA (0.62) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| P-Xylene SCHEMBL8660591 | 0.95 | GAA (0.62) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL34 | 0.95 | GAA (0.62) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL11432043 | 0.95 | GAA (0.62) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL29991938 | 0.95 | GAA (0.62) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL31313 | 0.95 | GAA (0.62) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL1345322 | 0.92 | GAA (0.59) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL22615915 | 0.92 | GAA (0.59) | GAAALDH1A1SMN1; SMN2LMNATDP1 | |
| Phosphine SCHEMBL3185895 | 0.92 | GAA (0.59) | GAAALDH1A1SMN1; SMN2LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11491244-B2 | Labeled fluorocarbon agents for positron emission tomography imaging | Sunnybrook Research Institute (CA) | 2022-11-08 | — | — | US | disclosed |
| US-20200397922-A1 | LABELED FLUOROCARBON AGENTS FOR POSITRON EMISSION TOMOGRAPHY IMAGING | MCMASTER UNIVERSITY (CA) | 2020-12-24 | — | — | US | disclosed |
| WO-2018218376-A1 | LABELED FLUOROCARBON AGENTS FOR POSITRON EMISSION TOMOGRAPHY IMAGING | MCMASTER UNIVERSITY (CA) | 2018-12-06 | — | — | WO | disclosed |
| CN-105263889-B | For purifying the method for the cholinomimetic of 18F- labels | 特拉西斯股份有限公司 | 2018-06-26 | — | — | CN | disclosed |
| CN-105263889-A | Method for purification of 18f-labeled choline analogues | TRASIS S A | 2016-01-20 | — | — | CN | disclosed |
| CN-102712552-B | Method for production of F-18 labeled glutamic acid derivatives | Bayer Pharma AG | 2015-07-22 | — | — | CN | disclosed |
| CN-103857660-A | For PET imaging18Direct synthesis of F-fluoromethoxy compounds and use thereof in direct radiosynthesis of O- ([ 2 ]18F]Novel precursors of protected derivatives of fluoromethyl) tyrosine | PIRAMAL IMAGING SA | 2014-06-11 | — | — | CN | disclosed |
| CN-102239162-B | Pyridazinone derivatives | HOFFMANN LA ROCHE | 2014-05-28 | — | — | CN | disclosed |
| CN-103339100-A | Isotopic carbon choline analogs | GE HEALTHCARE LTD | 2013-10-02 | — | — | CN | disclosed |
| CN-103282343-A | Choline analogue as radiotracer | GE HEALTHCARE LTD | 2013-09-04 | — | — | CN | disclosed |
| CN-102712552-A | Method for production of F-18 labeled glutamic acid derivatives | BAYER SCHERING PHARMA AG | 2012-10-03 | — | — | CN | disclosed |
| CN-102239162-A | Pyridazinone derivatives | HOFFMANN LA ROCHE | 2011-11-09 | — | — | CN | disclosed |
| CN-101855222-A | Imidazol (1,2-A)pyridines and related compounds with activity at cannabinoid CB2 receptors | GE HEALTHCARE LTD | 2010-10-06 | — | — | CN | disclosed |