Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.79 |
| ▸ | NCOR2 | Q9Y618 | 9/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20577367 | 1.00 | HDAC1 (0.79) | HDAC1HDAC3HDAC2NCOR2HDAC8 | |
| SCHEMBL18233524 | 0.76 | ALDH1A1 (0.76) | HDAC1HDAC3HDAC2NCOR2HDAC8 | |
| SCHEMBL20577385 | 0.75 | HDAC3 (1.00) | HDAC1HDAC3HDAC2NCOR2HDAC8 | |
| SCHEMBL20577384 | 0.75 | HDAC3 (1.00) | HDAC1HDAC3HDAC2NCOR2HDAC8 | |
| SCHEMBL20577362 | 0.73 | HDAC3 (1.00) | HDAC1HDAC3HDAC2NCOR2HDAC8 | |
| SCHEMBL20577365 | 0.73 | HDAC3 (1.00) | HDAC1HDAC3HDAC2NCOR2HDAC8 | |
| SCHEMBL7752354 | 0.69 | ALDH1A1 (0.82) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| SCHEMBL19074542 | 0.69 | ALDH1A1 (0.82) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| SCHEMBL5104098 | 0.68 | HTT (0.72) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| SCHEMBL23745953 | 0.67 | HDAC3 (0.76) | HDAC1HDAC3HDAC2NCOR2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018223122-A1 | HDAC3-SELECTIVE INHIBITORS | OHIO STATE INNOVATION FOUNDATION (US) | 2018-12-06 | — | — | WO | disclosed |