Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.49 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.47 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 10/20 | 0.46 |
| ▸ | ACE | P12821 | 10/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20583257 | 1.00 | GPR88 (0.49) | GPR88SRRPSAT1PDCD1CD274 | |
| SCHEMBL20583255 | 1.00 | GPR88 (0.49) | GPR88SRRPSAT1PDCD1CD274 | |
| SCHEMBL20583645 | 0.88 | MME (0.50) | GPR88SRRPSAT1MMEACE | |
| SCHEMBL20583644 | 0.88 | MME (0.50) | GPR88SRRPSAT1MMEACE | |
| SCHEMBL20583647 | 0.88 | MME (0.50) | GPR88SRRPSAT1MMEACE | |
| SCHEMBL8522871 | 0.88 | MME (0.50) | GPR88SRRPSAT1MMEACE | |
| SCHEMBL24404055 | 0.86 | GPR88 (0.49) | GPR88SRRPSAT1MMEACE | |
| SCHEMBL21572784 | 0.86 | GPR88 (0.49) | GPR88SRRPSAT1MMEACE | |
| SCHEMBL598890 | 0.86 | GPR88 (0.49) | GPR88SRRPSAT1MMEACE | |
| SCHEMBL597164 | 0.86 | GPR88 (0.49) | GPR88SRRPSAT1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-06-28 | — | — | US | disclosed |
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-06-28 | — | — | US | disclosed |
| EP-3424899-B1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2022-05-11 | — | — | EP | disclosed |
| EP-3424899-B1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2022-05-11 | — | — | EP | disclosed |
| CN-106977415-B | Intermediate of shakubiqu and preparation method thereof | 广东东阳光药业有限公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-107216277-B | Preparation method of LCZ696 medicine impurity | 东南大学 | 2020-04-24 | — | — | CN | disclosed |
| US-20200079721-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED (HK) | 2020-03-12 | — | — | US | disclosed |
| US-10479753-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD (CN) | 2019-11-19 | — | — | US | disclosed |
| US-10479753-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD (CN) | 2019-11-19 | — | — | US | disclosed |
| EP-3424899-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2019-01-09 | — | — | EP | disclosed |
| US-20180362439-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079721-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | DPP4, ACE, DPP8 | GPR88 1950/4885SRR 1242/4885PSAT1 634/4885 |
| US-20180362439-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | ACE, DPP4, SI | GPR88 2233/4885SRR 1241/4885PSAT1 758/4885 |
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | DPP4, ACE, DPP8 | GPR88 1950/4885SRR 1242/4885PSAT1 634/4885 |
| US-10479753-B2 | Sacubitril intermediate and preparation method thereof | ACE, DPP4, SI | GPR88 2233/4885SRR 1241/4885PSAT1 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.