SCHEMBL20588786

SCHEMBL20588786

CCOC(=O)[C@]1(OC(=O)C(Cl)Cl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 11/20 0.69
▸ CYP3A4 P08684 4/20 0.69
▸ PGR P06401 4/20 0.69
▸ USP2 O75604 3/20 0.69
▸ LMNA P02545 2/20 0.69
▸ NR1I2 O75469 2/20 0.69
▸ MAPT P10636 2/20 0.69
▸ MLNR O43193 1/20 0.69
▸ ABCB11 O95342 1/20 0.69
▸ CYP3A5 P20815 1/20 0.69
▸ PPARG P37231 1/20 0.69
▸ SMN1; SMN2 Q16637 1/20 0.69
▸ NPSR1 Q6W5P4 1/20 0.69
▸ CYP2D6 P10635 1/20 0.69
▸ CYP2C9 P11712 1/20 0.69
▸ ADORA3 P0DMS8 1/20 0.68
▸ DRD2 P14416 1/20 0.68
▸ OPRD1 P41143 1/20 0.68
▸ MMP1 P03956 8/20 0.66
▸ MEN1 O00255 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8503026 1.00 NR3C1 (0.69) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL7608277 1.00 NR3C1 (0.69) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL7616620 0.94 NR3C1 (0.69) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL8506353 0.94 NR3C1 (0.69) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL8502507 0.94 NR3C1 (0.67) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL8504838 0.94 NR3C1 (0.67) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL7616536 0.92 NR3C1 (0.67) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL20589425 0.92 NR3C1 (0.67) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL8505887 0.92 NR3C1 (0.67) NR3C1CYP3A4PGRUSP2LMNA
SCHEMBL7611068 0.92 NR3C1 (0.64) NR3C1CYP3A4PGRUSP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11447522-B2 Potent soft anti-inflammatory corticosteroid compounds and uses thereof BODOR LABORATORIES, INC. (US) 2022-09-20 — — US disclosed
US-20200181191-A1 POTENT SOFT ANTI-INFLAMMATORY CORTICOSTEROID COMPOUNDS AND USES THEREOF BODOR LABORATORIES, INC. 2020-06-11 — — US disclosed
EP-3638249-A1 POTENT SOFT ANTI-INFLAMMATORY CORTICOSTEROID COMPOUNDS AND USES THEREOF Bodor Laboratories, Inc. (US) 2020-04-22 — — EP disclosed
WO-2018232007-A1 POTENT SOFT ANTI-INFLAMMATORY CORTICOSTEROID COMPOUNDS AND USES THEROF BODOR LABORATORIES, INC. (US) 2018-12-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200181191-A1 POTENT SOFT ANTI-INFLAMMATORY CORTICOSTEROID COMPOUNDS AND USES THEREOF NR3C1, NR3C2, HSD3B1 NR3C1 1/4885CYP3A4 334/4885PGR 401/4885
US-11447522-B2 Potent soft anti-inflammatory corticosteroid compounds and uses thereof NR3C1, NR3C2, HSD3B1 NR3C1 1/4885CYP3A4 334/4885PGR 401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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