Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858351 | 0.89 | HSP90AB1 (0.59) | HSP90AB1VCAM1GAAALDH1A1GFER | |
| SCHEMBL2786552 | 0.85 | HSP90AB1 (0.63) | HSP90AB1GAAALDH1A1GFERKMT2A | |
| SCHEMBL28118610 | 0.81 | HSP90AB1 (0.58) | HSP90AB1GAAALDH1A1GFERKMT2A | |
| SCHEMBL29961027 | 0.81 | HSP90AB1 (0.58) | HSP90AB1GAAALDH1A1GFERKMT2A | |
| SCHEMBL7069525 | 0.80 | HSP90AB1 (0.56) | HSP90AB1GAAALDH1A1GFERKMT2A | |
| SCHEMBL20599348 | 0.79 | HSP90AB1 (0.42) | HSP90AB1VCAM1GAAALDH1A1GFER | |
| SCHEMBL31075998 | 0.78 | HSP90AB1 (0.54) | HSP90AB1GAAALDH1A1GFERKMT2A | |
| SCHEMBL7073645 | 0.78 | HSP90AB1 (0.54) | HSP90AB1GAAALDH1A1GFERKMT2A | |
| SCHEMBL1525224 | 0.78 | HSP90AB1 (0.54) | HSP90AB1GAAALDH1A1GFERKMT2A | |
| SCHEMBL21553597 | 0.78 | GAA (0.50) | VCAM1GAAALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645532-B9 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT FOR PREPARING OPHTHALMIC DEVICES, SUCH AS E.G. CONTACT LENSES | JOHNSON & JOHNSON VISION CARE (US) | 2022-08-31 | — | — | EP | disclosed |
| EP-3645532-B1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT FOR PREPARING OPHTHALMIC DEVICES, SUCH AS E.G. CONTACT LENSES | JOHNSON & JOHNSON VISION CARE (US) | 2022-05-11 | — | — | EP | disclosed |
| EP-3645532-B1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT FOR PREPARING OPHTHALMIC DEVICES, SUCH AS E.G. CONTACT LENSES | JOHNSON & JOHNSON VISION CARE (US) | 2022-05-11 | — | — | EP | disclosed |
| US-10723732-B2 | Hydroxyphenyl phenanthrolines as polymerizable blockers of high energy light | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20190002459-A1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT | JOHNSON & JOHNSON VISION CARE, INC. | 2019-01-03 | — | — | US | disclosed |
| WO-2019003064-A1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT FOR PREPARING OPHTHALMIC DEVICES, SUCH AS E.G. CONTACT LENSES | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002459-A1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT | HRH2, HRH3, HRH1 | HSP90AB1 51/4885VCAM1 1137/4885GAA 3475/4885 |
| US-10723732-B2 | Hydroxyphenyl phenanthrolines as polymerizable blockers of high energy light | HRH2, HRH3, HRH1 | HSP90AB1 51/4885VCAM1 1137/4885GAA 3475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.