Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 6/20 | 0.40 |
| ▸ | THRA | P10827 | 5/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20599232 | 0.79 | HSP90AB1 (0.51) | HSP90AB1VCAM1ALOX15TSHRLMNA | |
| SCHEMBL20620697 | 0.77 | DGAT1 (0.35) | HSP90AB1VCAM1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL28680697 | 0.75 | HSP90AB1 (0.56) | HSP90AB1THRBTHRAALOX15TSHR | |
| SCHEMBL6033258 | 0.74 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL28734927 | 0.74 | CA2 (0.46) | MAPTKDM4EKMT2AALDH1A1GAA | |
| SCHEMBL5086986 | 0.74 | CYP2D6 (0.38) | HSD17B10LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL13148462 | 0.74 | HSP90AB1 (0.45) | HSP90AB1VCAM1TSHRLMNAMAPT | |
| SCHEMBL6858351 | 0.74 | HSP90AB1 (0.59) | HSP90AB1VCAM1ALOX15TSHRLMNA | |
| SCHEMBL13170232 | 0.73 | HSP90AB1 (0.47) | HSP90AB1VCAM1TSHRLMNAMAPT | |
| SCHEMBL28734957 | 0.73 | HTR2A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645532-B9 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT FOR PREPARING OPHTHALMIC DEVICES, SUCH AS E.G. CONTACT LENSES | JOHNSON & JOHNSON VISION CARE (US) | 2022-08-31 | — | — | EP | disclosed |
| EP-3645532-B1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT FOR PREPARING OPHTHALMIC DEVICES, SUCH AS E.G. CONTACT LENSES | JOHNSON & JOHNSON VISION CARE (US) | 2022-05-11 | — | — | EP | disclosed |
| EP-3645532-B1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT FOR PREPARING OPHTHALMIC DEVICES, SUCH AS E.G. CONTACT LENSES | JOHNSON & JOHNSON VISION CARE (US) | 2022-05-11 | — | — | EP | disclosed |
| US-10723732-B2 | Hydroxyphenyl phenanthrolines as polymerizable blockers of high energy light | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20190002459-A1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT | JOHNSON & JOHNSON VISION CARE, INC. | 2019-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002459-A1 | HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT | HRH2, HRH3, HRH1 | HSP90AB1 51/4885THRB 2569/4885THRA 2655/4885 |
| US-10723732-B2 | Hydroxyphenyl phenanthrolines as polymerizable blockers of high energy light | HRH2, HRH3, HRH1 | HSP90AB1 51/4885THRB 2569/4885THRA 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.