Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL777012 | 0.85 | MEN1 (0.34) | RAPGEF4MEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL11808764 | 0.85 | RAPGEF4 (0.36) | RAPGEF4MEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL8140524 | 0.85 | ALDH1A1 (0.37) | RAPGEF4MEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL8380604 | 0.83 | MEN1 (0.36) | RAPGEF4MEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL10600448 | 0.83 | MAPK1 (0.47) | MEN1ALDH1A1KMT2ALMNAHSD17B10 | |
| SCHEMBL15458074 | 0.79 | RAPGEF4 (0.34) | RAPGEF4LMNASMN1; SMN2MAPK1NPC1 | |
| SCHEMBL775800 | 0.79 | SMN1; SMN2 (0.40) | RAPGEF4MEN1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL776652 | 0.79 | FFAR4 (0.40) | MEN1ALDH1A1KMT2AHSD17B10GAA | |
| SCHEMBL16975313 | 0.79 | SMN1; SMN2 (0.40) | RAPGEF4MEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL20504171 | 0.79 | SMN1; SMN2 (0.32) | RAPGEF4MEN1ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019000237-A1 | 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2019-01-03 | — | — | WO | disclosed |