Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.55 |
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | FLT1 | P17948 | 4/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30425807 | 1.00 | PDGFRB (0.55) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL29783603 | 0.78 | FGFR1 (0.78) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL20624880 | 0.78 | FGFR1 (0.50) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL23326112 | 0.78 | FGFR1 (0.78) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL23326153 | 0.77 | FGFR1 (0.79) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL28401037 | 0.77 | PDGFRB (0.47) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL1052596 | 0.76 | FGFR1 (0.74) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL1052433 | 0.76 | FGFR1 (0.74) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL1055032 | 0.76 | FGFR1 (0.74) | PDGFRBFGFR1KDRFLT1CHEK1 | |
| SCHEMBL21660654 | 0.76 | PDPK1 (0.50) | PDGFRBFGFR1KDRFLT1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032643-B | Quinolinone compounds | 詹森药业有限公司 | 2023-05-30 | — | — | CN | disclosed |
| US-11384075-B2 | Quinolinone compounds | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-12 | — | — | US | disclosed |
| US-20210139470-A1 | New Quinolinone Compounds | JOHNSON & JOHNSON (CHINA) INVESTMENT LTD. (CN) | 2021-05-13 | — | — | US | disclosed |
| EP-3645526-A1 | NEW QUINOLINONE COMPOUNDS | Janssen Pharmaceutica NV (BE) | 2020-05-06 | — | — | EP | disclosed |
| CN-111032643-A | Quinolinone compounds | 詹森药业有限公司 | 2020-04-17 | — | — | CN | disclosed |
| WO-2019001419-A1 | NEW QUINOLINONE COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139470-A1 | New Quinolinone Compounds | FGFR1, FGFR2, FGFR3 | PDGFRB 31/4885FGFR1 1/4885KDR 28/4885 |
| US-11384075-B2 | Quinolinone compounds | FGFR1, FGFR2, FGFR3 | PDGFRB 23/4885FGFR1 1/4885KDR 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.