Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 18/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 15/20 | 0.79 |
| ▸ | KDR | P35968 | 15/20 | 0.79 |
| ▸ | FLT1 | P17948 | 6/20 | 0.79 |
| ▸ | LCK | P06239 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | STK25 | O00506 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | CHUK | O15111 | 1/20 | 0.62 |
| ▸ | MUSK | O15146 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29783603 | 0.89 | FGFR1 (0.78) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL23326112 | 0.89 | FGFR1 (0.78) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL17433339 | 0.88 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL14795687 | 0.81 | FGFR1 (0.84) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL3381227 | 0.80 | FGFR1 (0.85) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL3381059 | 0.80 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL14795663 | 0.79 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL12834057 | 0.79 | FGFR1 (0.71) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL23326256 | 0.78 | FGFR3 (0.68) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL20625529 | 0.78 | FGFR3 (0.68) | FGFR1PDGFRBKDRFLT1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11384075-B2 | Quinolinone compounds | JANSSEN PHARMACEUTICA NV (BE) | 2022-07-12 | — | — | US | disclosed |
| US-20210139470-A1 | New Quinolinone Compounds | JOHNSON & JOHNSON (CHINA) INVESTMENT LTD. (CN) | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139470-A1 | New Quinolinone Compounds | FGFR1, FGFR2, FGFR3 | FGFR1 1/4885PDGFRB 31/4885KDR 28/4885 |
| US-11384075-B2 | Quinolinone compounds | FGFR1, FGFR2, FGFR3 | FGFR1 1/4885PDGFRB 23/4885KDR 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.