Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20600302 | 0.88 | CCR4 (0.52) | FLT3KDM1ARAB9AKMT2ANPC1 | |
| SCHEMBL20600296 | 0.87 | KDM1A (0.61) | FLT3KDM1ARAB9AKMT2ANPC1 | |
| SCHEMBL20600312 | 0.86 | RAB9A (0.57) | FLT3KDM1ARAB9AKMT2ANPC1 | |
| SCHEMBL20600402 | 0.82 | KDM1A (0.58) | FLT3KDM1ARAB9ANPC1MAPK14 | |
| SCHEMBL20600417 | 0.82 | FLT3 (0.47) | FLT3KDM1ARAB9AKMT2ANPC1 | |
| SCHEMBL20600109 | 0.82 | SMN1; SMN2 (0.49) | FLT3KDM1ARAB9AKMT2ANPC1 | |
| SCHEMBL20600165 | 0.81 | SMN1; SMN2 (0.51) | FLT3KDM1ARAB9AKMT2ANPC1 | |
| SCHEMBL20600407 | 0.81 | MAPK14 (0.58) | FLT3KDM1ARAB9AKMT2ANPC1 | |
| SCHEMBL20600418 | 0.80 | FLT3 (0.48) | FLT3KDM1ARAB9AKMT2ANPC1 | |
| SCHEMBL20621090 | 0.80 | FLT3 (0.48) | FLT3KDM1ARAB9AKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645531-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2020-05-06 | — | — | EP | claimed |
| US-20200123147-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-04-23 | — | — | US | claimed |
| WO-2019002074-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2019-01-03 | — | — | WO | claimed |
| EP-3645531-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2020-05-06 | — | — | EP | disclosed |
| US-20200123147-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-04-23 | — | — | US | disclosed |
| US-20200123147-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-04-23 | — | — | US | disclosed |
| WO-2019002074-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123147-A1 | THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | FLT3 477/4885KDM1A 162/4885RAB9A 2145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.