⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20600798 | 0.79 | TTR (0.34) | — | |
| SCHEMBL20600603 | 0.79 | — | — | |
| SCHEMBL20600827 | 0.78 | KDR (0.32) | — | |
| SCHEMBL28204123 | 0.76 | CYP3A4 (0.37) | — | |
| SCHEMBL8012765 | 0.75 | HSD17B10 (0.46) | — | |
| SCHEMBL20600854 | 0.72 | NQO2 (0.38) | — | |
| SCHEMBL18876146 | 0.72 | HSD11B1 (0.35) | — | |
| SCHEMBL15150618 | 0.72 | TGFBR1 (0.30) | — | |
| Ammonia Solution, Strong SCHEMBL28632131 | 0.70 | HSD11B1 (0.34) | — | |
| SCHEMBL29324218 | 0.70 | POLB (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200369665-A1 | IMIDAZO[1,2-A]PYRAZINE MODULATORS OF THE ADENOSINE A2A RECEPTOR | Ryvu Therapeutics S.A. (PL) | 2020-11-26 | — | — | US | disclosed |
| EP-3645536-A1 | IMIDAZO[1,2-A]PYRAZINE MODULATORS OF THE ADENOSINE A2A RECEPTOR | Ryvu Therapeutics S.A. (PL) | 2020-05-06 | — | — | EP | disclosed |
| CN-110809577-A | Modulators of adenosine A2A receptor | 雷沃医疗有限公司 | 2020-02-18 | — | — | CN | disclosed |
| WO-2019002606-A1 | IMIDAZO[1,2-A]PYRAZINE MODULATORS OF THE ADENOSINE A2A RECEPTOR | SELVITA S.A. (PL) | 2019-01-03 | — | — | WO | disclosed |