Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | STS | P08842 | 1/20 | 0.52 |
| ▸ | YAP1 | P46937 | 2/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.49 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732370 | 0.88 | KDM4E (0.67) | KDM4EPKMGPR119MEN1KMT2A | |
| SCHEMBL20618575 | 0.87 | KDM4E (0.65) | KDM4EPKMGPR119MEN1KMT2A | |
| SCHEMBL15537093 | 0.87 | KMT2A (0.58) | KDM4EPKMGPR119MEN1KMT2A | |
| SCHEMBL8346703 | 0.86 | GPR119 (0.56) | KDM4EPKMGPR119MEN1KMT2A | |
| SCHEMBL3525137 | 0.86 | KDM4E (0.55) | KDM4EPKMGPR119MEN1KMT2A | |
| SCHEMBL8346803 | 0.86 | KDM4E (0.55) | KDM4EPKMGPR119YAP1TGFBR1 | |
| SCHEMBL30848494 | 0.86 | KDM4E (0.55) | KDM4EPKMGPR119YAP1TGFBR1 | |
| SCHEMBL20601273 | 0.85 | KDM4E (0.63) | KDM4EPKMGPR119MEN1KMT2A | |
| SCHEMBL20601271 | 0.85 | KDM4E (0.63) | KDM4EPKMGPR119MEN1KMT2A | |
| SCHEMBL20618530 | 0.85 | KDM4E (0.63) | KDM4EPKMGPR119MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210078988-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-03-18 | — | — | US | disclosed |
| US-20210078988-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-03-18 | — | — | US | disclosed |
| EP-3645519-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-05-06 | — | — | EP | disclosed |
| CN-110770222-A | Modulators of indoleamine2, 3-dioxygenase | 葛兰素史克知识产权开发有限公司 | 2020-02-07 | — | — | CN | disclosed |
| WO-2019003142-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-03 | — | — | WO | disclosed |
| WO-2019003142-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078988-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, TPH1 | KDM4E 657/4885PKM 892/4885GPR119 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.