Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | GLA | P06280 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CASP1 | P29466 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | CASP7 | P55210 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1175533 | 0.89 | KMT2A (0.82) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL308621 | 0.88 | KMT2A (0.61) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3490895 | 0.88 | KMT2A (0.61) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL308831 | 0.85 | KMT2A (0.57) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1546722 | 0.84 | KMT2A (0.57) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4509653 | 0.83 | EPHX2 (0.60) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1175762 | 0.83 | HDAC3 (0.60) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1547311 | 0.81 | KMT2A (0.53) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20616582 | 0.81 | KMT2A (0.55) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1979356 | 0.81 | KDM4E (0.59) | KMT2AHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10906924-B2 | Modulators of indoleamine 2,3-dioxygenase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-02-02 | — | — | US | disclosed |
| US-10906924-B2 | Modulators of indoleamine 2,3-dioxygenase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-02-02 | — | — | US | disclosed |
| US-20200165280-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-05-28 | — | — | US | disclosed |
| US-20200165280-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-05-28 | — | — | US | disclosed |
| EP-3645538-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019003148-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-03 | — | — | WO | disclosed |
| WO-2019003148-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165280-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, TPH1 | KMT2A 1143/4885HDAC3 185/4885HDAC4 869/4885 |
| US-10906924-B2 | Modulators of indoleamine 2,3-dioxygenase | IDO1, IDO2, TPH1 | KMT2A 1143/4885HDAC3 185/4885HDAC4 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.