Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 1/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25439322 | 0.83 | SLC6A12 (0.37) | SLC6A12SLC6A11LMNAHPGDGRM4 | |
| SCHEMBL21458309 | 0.65 | SLC6A12 (0.45) | SLC6A12SLC6A11LMNAGRM4CYP2C19 | |
| SCHEMBL11638654 | 0.65 | SLC6A12 (0.41) | SLC6A12SLC6A11GRM4CYP2C19MEN1 | |
| SCHEMBL301094 | 0.61 | — | — | |
| SCHEMBL1634054 | 0.61 | LMNA (0.39) | SLC6A12SLC6A11LMNAHPGDGRM4 | |
| SCHEMBL1634637 | 0.59 | LMNA (0.38) | SLC6A12SLC6A11LMNAHPGDGRM4 | |
| SCHEMBL1634232 | 0.59 | LMNA (0.38) | SLC6A12SLC6A11LMNAHPGDGRM4 | |
| SCHEMBL16409165 | 0.59 | — | — | |
| SCHEMBL1635774 | 0.59 | LMNA (0.38) | SLC6A12SLC6A11LMNAHPGDGRM4 | |
| SCHEMBL1634171 | 0.59 | LMNA (0.38) | SLC6A12SLC6A11LMNAHPGDGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645533-A1 | TDO2 AND IDO1 INHIBITORS | Genentech, Inc. (US) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019005559-A1 | TDO2 AND IDO1 INHIBITORS | GENENTECH, INC. (US) | 2019-01-03 | — | — | WO | disclosed |