SCHEMBL20604136

SCHEMBL20604136

Cc1nn(-c2ccccc2Br)c(C)c1C(=O)Nc1ccc2ccccc2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
WNT3A P56704 11/20 1.00
NPC1 O15118 5/20 0.55
RAB9A P51151 5/20 0.55
GSK3B P49841 1/20 0.53
MTOR P42345 1/20 0.52
SORT1 Q99523 1/20 0.44
ADORA3 P0DMS8 1/20 0.43
ADORA2A P29274 1/20 0.43
ADORA2B P29275 1/20 0.43
ADORA1 P30542 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30387581 1.00 WNT3A (1.00) WNT3ANPC1RAB9AGSK3BMTOR
SCHEMBL30387435 0.85 WNT3A (1.00) WNT3ANPC1RAB9AGSK3B
SCHEMBL20604154 0.85 WNT3A (1.00) WNT3ANPC1RAB9AGSK3B
SCHEMBL20604207 0.83 WNT3A (1.00) WNT3ANPC1RAB9AGSK3BMTOR
SCHEMBL30386560 0.83 WNT3A (1.00) WNT3ANPC1RAB9AGSK3BMTOR
SCHEMBL20604091 0.80 WNT3A (0.80) WNT3ANPC1RAB9AGSK3BMTOR
SCHEMBL30388094 0.80 WNT3A (0.80) WNT3ANPC1RAB9AGSK3BMTOR
SCHEMBL20604119 0.80 WNT3A (1.00) WNT3ANPC1RAB9AGSK3BMTOR
SCHEMBL30002584 0.80 WNT3A (1.00) WNT3ANPC1RAB9AGSK3BMTOR
SCHEMBL30388044 0.80 WNT3A (1.00) WNT3ANPC1RAB9AGSK3BMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260138966-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIV OF MARYLAND BALTIMORE (US) 2026-05-21 US claimed
US-10882841-B2 Wnt signaling pathway inhibitors for treatments of disease UNIVERSITY OF MARYLAND, BALTIMORE (US) 2021-01-05 US claimed
US-20200299261-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIVERSITY OF MARYLAND, BALTIMORE 2020-09-24 US claimed
US-10723715-B2 2020-07-28 US claimed
US-20190071424-A1 WNT Signaling Pathway Inhibitors for Treatments of Disease UNIVERSITY OF MARYLAND, BALTIMORE 2019-03-07 US claimed
EP-3423452-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE University of Maryland, Baltimore (US) 2019-01-09 EP claimed
US-20260138966-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIV OF MARYLAND BALTIMORE (US) 2026-05-21 US disclosed
US-12378220-B2 WNT signaling pathway inhibitors for treatments of disease UNIVERSITY OF MARYLAND, BALTIMORE (US) 2025-08-05 US disclosed
EP-3423452-B1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIV MARYLAND (US) 2025-05-07 EP disclosed
US-20240208927-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIVERSITY OF MARYLAND, BALTIMORE 2024-06-27 US disclosed
US-20240208927-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIVERSITY OF MARYLAND, BALTIMORE 2024-06-27 US disclosed
US-20240208927-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIVERSITY OF MARYLAND, BALTIMORE 2024-06-27 US disclosed
US-11655233-B2 WNT signaling pathway inhibitors for treatments of disease UNIVERSITY OF MARYLAND, BALTIMORE (US) 2023-05-23 US disclosed
US-20200299261-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIVERSITY OF MARYLAND, BALTIMORE 2020-09-24 US disclosed
US-20200299261-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE UNIVERSITY OF MARYLAND, BALTIMORE 2020-09-24 US disclosed
US-10723715-B2 2020-07-28 US disclosed
US-10723715-B2 2020-07-28 US disclosed
US-20190071424-A1 WNT Signaling Pathway Inhibitors for Treatments of Disease UNIVERSITY OF MARYLAND, BALTIMORE 2019-03-07 US disclosed
US-20190071424-A1 WNT Signaling Pathway Inhibitors for Treatments of Disease UNIVERSITY OF MARYLAND, BALTIMORE 2019-03-07 US disclosed
EP-3423452-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE University of Maryland, Baltimore (US) 2019-01-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10882841-B2 Wnt signaling pathway inhibitors for treatments of disease WNT1, CTNNB1, WNT3A WNT3A 3/4885NPC1 301/4885RAB9A 1473/4885
US-20200299261-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE WNT1, CTNNB1, WNT3A WNT3A 3/4885NPC1 301/4885RAB9A 1473/4885
US-12378220-B2 WNT signaling pathway inhibitors for treatments of disease WNT1, CTNNB1, WNT3A WNT3A 3/4885NPC1 301/4885RAB9A 1473/4885
US-20190071424-A1 WNT Signaling Pathway Inhibitors for Treatments of Disease WNT1, CTNNB1, WNT3A WNT3A 3/4885NPC1 301/4885RAB9A 1473/4885
US-11655233-B2 WNT signaling pathway inhibitors for treatments of disease WNT1, CTNNB1, WNT3A WNT3A 3/4885NPC1 301/4885RAB9A 1473/4885
US-20260138966-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE CTNNB1, WNT1, CTNND1 WNT3A 5/4885NPC1 598/4885RAB9A 1686/4885
US-20240208927-A1 WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE WNT1, CTNNB1, WNT3A WNT3A 3/4885NPC1 301/4885RAB9A 1473/4885
US-10723715-B2 CTNNB1, WNT1, CTNNBL1 WNT3A 4/4885NPC1 138/4885RAB9A 1667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.