Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20604584 | 0.85 | FFAR4 (0.49) | KDM1ACDC7CYP19A1FFAR4ENPP3 | |
| SCHEMBL10193341 | 0.83 | ROCK1 (0.55) | ROCK1PDGFRBPDGFRAL3MBTL1KCNH2 | |
| SCHEMBL12069041 | 0.82 | SCN9A (0.52) | CDC7CYP19A1TDP2FFAR4ENPP3 | |
| SCHEMBL10637458 | 0.82 | EGFR (0.46) | KDM1ACDC7TDP2ENPP3CDK2 | |
| SCHEMBL22359855 | 0.81 | FFAR4 (0.53) | CDC7CYP19A1FFAR4ENPP3CDK2 | |
| SCHEMBL6583376 | 0.81 | KCNH2 (0.56) | CDC7CYP19A1TDP2FFAR4ENPP3 | |
| SCHEMBL4282844 | 0.80 | ENPP3 (0.56) | CDC7CYP19A1TDP2FFAR4ENPP3 | |
| SCHEMBL20604726 | 0.80 | FFAR4 (0.44) | CDC7CYP19A1FFAR4ENPP3CDK2 | |
| SCHEMBL20025721 | 0.78 | L3MBTL1 (0.44) | KDM1ACYP19A1TDP2L3MBTL1 | |
| SCHEMBL15228837 | 0.78 | CDC7 (0.45) | CDC7CYP19A1FFAR4ENPP3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423443-B1 | CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS | NOVARTIS AG (CH) | 2020-08-19 | — | — | EP | disclosed |
| US-10590079-B2 | Cyano-substituted indoles as LSD1 inhibitors | NOVARTIS AG (CH) | 2020-03-17 | — | — | US | disclosed |
| CN-110267945-A | The benzazolyl compounds that cyano replaces and its purposes as LSD1 inhibitor | 诺华股份有限公司 | 2019-09-20 | — | — | CN | disclosed |
| US-20190092724-A1 | CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS | NOVARTIS AG (CH) | 2019-03-28 | — | — | US | disclosed |
| US-20190092724-A1 | CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS | NOVARTIS AG (CH) | 2019-03-28 | — | — | US | disclosed |
| EP-3423443-A1 | CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS | Novartis AG (CH) | 2019-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590079-B2 | Cyano-substituted indoles as LSD1 inhibitors | KDM1A, KDM1B, KDM3A | KDM1A 1/4885CDC7 1070/4885CYP19A1 339/4885 |
| US-20190092724-A1 | CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS | KDM1A, KDM1B, KDM2A | KDM1A 1/4885CDC7 1316/4885CYP19A1 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.