Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of L-Adrenaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 8/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.79 |
| ▸ | ADRB3 known ✓ | P13945 | 4/20 | 0.79 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.79 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.79 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.79 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.79 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.79 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 1.00 |
| ▸ | BLM | P54132 | 7/20 | 1.00 |
| ▸ | TSHR | P16473 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racepinephrine SCHEMBL29587492 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL29457688 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL27968525 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL40742 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL4406973 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| L-Adrenaline SCHEMBL26986346 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL40741 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL28412215 | 0.98 | KDM4E (0.97) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL4066533 | 0.98 | KDM4E (0.97) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL7394380 | 0.91 | KDM4E (0.83) | KDM4ETDP1MAPTADRB2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380703-A | Refining method of adrenaline | 蚌埠丰原医药科技发展有限公司 | 2022-04-22 | — | — | CN | disclosed |
| US-20200085765-A1 | SAFER AND MORE EFFECTIVE METHODS OF TRANSMUCOSAL, INCLUDING INTRANASAL, DELIVERY FOR RAISING BLOOD PRESSURE AND STIMULATING THE BODY | TRUIST BANK, AS ADMINISTRATIVE AGENT | 2020-03-19 | — | — | US | disclosed |
| US-20200069582-A1 | INHALABLE HEMODYNAMIC AGENTS AND METHODS OF USING THE SAME | TRUIST BANK, AS ADMINISTRATIVE AGENT | 2020-03-05 | — | — | US | disclosed |
| US-20190008759-A1 | SAFER AND MORE EFFECTIVE METHODS OF TRANSMUCOSAL DELIVERY FOR RAISING BLOOD PRESSURE AND STIMULATING THE BODY | TRUIST BANK, AS ADMINISTRATIVE AGENT | 2019-01-10 | — | — | US | disclosed |