Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Epinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 8/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.79 |
| ▸ | ADRB3 known ✓ | P13945 | 4/20 | 0.79 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.79 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.79 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.79 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.79 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.79 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 1.00 |
| ▸ | BLM | P54132 | 7/20 | 1.00 |
| ▸ | TSHR | P16473 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racepinephrine SCHEMBL29587492 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL29457688 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| L-Adrenaline SCHEMBL20608410 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL27968525 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL40742 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL4406973 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| L-Adrenaline SCHEMBL26986346 | 1.00 | KDM4E (1.00) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL28412215 | 0.98 | KDM4E (0.97) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL4066533 | 0.98 | KDM4E (0.97) | KDM4ETDP1MAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL7394380 | 0.91 | KDM4E (0.83) | KDM4ETDP1MAPTADRB2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2466 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3723819-B1 | WOUND DRESSING | ANIMAL ETHICS PTY LTD (AU) | 2026-04-22 | — | — | EP | claimed |
| EP-3866774-B1 | SUBLINGUAL EPINEPHRINE COMPOSITIONS INCLUDING PH-MODIFYING EXCIPIENTS AND PENETRATION ENHANCERS AND METHODS FOR USE THEREOF | UNIV NOVA SOUTHEASTERN (US) | 2026-01-28 | — | — | EP | claimed |
| US-20260007619-A1 | Sublingual Epinephrine Compositions Including pH-Modifying Excipients And Penetration Enhancers And Methods for Use Thereof | NOVA SOUTHEASTERN UNIVERSITY (US) | 2026-01-08 | — | — | US | claimed |
| EP-3678643-B1 | SUBLINGUAL EPINEPHRINE TABLETS | pHase Pharmaceuticals LLC (US) | 2025-11-26 | — | — | EP | claimed |
| US-20250262173-A1 | INTRANASAL EPINEPHRINE FORMULATIONS AND METHODS OF USE | RA CAPITAL AGENCY SERVICES, LLC, AS ADMINISTRATIVE AGENT FOR THE SECURED PARTIES | 2025-08-21 | — | — | US | claimed |
| US-12357591-B2 | Sublingual epinephrine compositions including pH-modifying excipients and penetration enhancers and methods for use thereof | NOVA SOUTHEASTERN UNIVERSITY (US) | 2025-07-15 | — | — | US | claimed |
| WO-2025125897-A1 | DEVICES FOR INJECTING MEDICAMENTS AND METHODS OF USE | MCDERMOTT LABORATORIES LIMITED (IE) | 2025-06-19 | — | — | WO | claimed |
| EP-4568660-A1 | INHALABLE EPINEPHRINE FORMULATION | De Motu Cordis Pty Ltd (AU) | 2025-06-18 | — | — | EP | claimed |
| US-12290493-B2 | More potent and less toxic formulations of epinephrine and methods of medical use | ADVANCED RESPIRATORY TECHNOLOGIES, INC. (US) | 2025-05-06 | — | — | US | claimed |
| CN-119768160-A | Inhalable adrenergic formulations | 德莫图科迪斯私人有限公司 | 2025-04-04 | — | — | CN | claimed |
| US-5518730-A | Biodegradable controlled release flash flow melt-spun delivery system | FUISZ TECHNOLOGIES LTD. (US) | 1996-05-21 | — | — | US | claimed |
| EP-0746342-A4 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES LTD (US) | 1996-01-11 | — | — | EP | claimed |
| EP-0536204-B1 | THE USE OF SOLUBLE FLUOROSURFACTANTS FOR THE PREPARATION OF METERED-DOSE AEROSOL FORMULATIONS | MINNESOTA MINING & MFG (US) | 1994-04-06 | — | — | EP | claimed |
| WO-1993024154-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES, LTD. (US) | 1993-12-09 | — | — | WO | claimed |
| EP-0536204-A1 | THE USE OF SOLUBLE FLUOROSURFACTANTS FOR THE PREPARATION OF METERED-DOSE AEROSOL FORMULATIONS. | MINNESOTA MINING & MFG (US) | 1993-04-14 | — | — | EP | claimed |
| WO-1992000062-A1 | THE USE OF SOLUBLE FLUOROSURFACTANTS FOR THE PREPARATION OF METERED-DOSE AEROSOL FORMULATIONS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1992-01-09 | — | — | WO | claimed |
| US-4352789-A | COATING OF PERFLUORINATED SURFACTANT; INHALANTS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-10-05 | — | — | US | claimed |
| US-4190642-A | Ocular therapeutic system for dispensing a medication formulation | ALZA CORPORATION (US) | 1980-02-26 | — | — | US | claimed |
| US-4177256-A | Osmotic bursting drug delivery device | ALZA CORPORATION (US) | 1979-12-04 | — | — | US | claimed |
| US-3968245-A | Sympathomimetic topical and percutaneous administration with halogenated promoters | ALZA CORPORATION (US) | 1976-07-06 | — | — | US | claimed |