⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872396 | 0.75 | TDP1 (0.33) | — | |
| SCHEMBL27391934 | 0.74 | TDP1 (0.35) | — | |
| SCHEMBL10001209 | 0.74 | CA1 (0.39) | — | |
| SCHEMBL20374767 | 0.73 | — | — | |
| SCHEMBL27419998 | 0.68 | KMT2A (0.33) | — | |
| SCHEMBL1697359 | 0.67 | KMT2A (0.33) | — | |
| SCHEMBL26382115 | 0.62 | HSD11B1 (0.34) | — | |
| SCHEMBL23683798 | 0.61 | KMT2A (0.30) | — | |
| SCHEMBL23841160 | 0.61 | SPHK2 (0.36) | — | |
| SCHEMBL15498526 | 0.61 | TDP1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10960046-B2 | Method of treating melanocortin-4 receptor pathway-associated disorders | RHYTHM PHARMACEUTICALS, INC. (US) | 2021-03-30 | — | — | US | disclosed |
| US-10167312-B2 | Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers | RHYTHM PHARMACEUTICALS, INC. (US) | 2019-01-01 | — | — | US | disclosed |