Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20630953 | 0.82 | MAPT (0.43) | MEN1KMT2AMAPTL3MBTL1MAPK1 | |
| SCHEMBL20630443 | 0.81 | CD274 (0.42) | MEN1KMT2AMAPTL3MBTL1MAPK1 | |
| SCHEMBL20630928 | 0.80 | MAPT (0.39) | MAPTL3MBTL1MAPK1TDP1CD274 | |
| SCHEMBL20631398 | 0.79 | TP53 (0.49) | MEN1KMT2AMAPTL3MBTL1MAPK1 | |
| SCHEMBL20630917 | 0.79 | SCN8A (0.43) | MAPTL3MBTL1MAPK1TDP1CD274 | |
| SCHEMBL20630462 | 0.79 | L3MBTL1 (0.50) | MAPTL3MBTL1MAPK1TDP1CD274 | |
| SCHEMBL20630447 | 0.77 | L3MBTL1 (0.49) | KMT2AMAPTL3MBTL1MAPK1TDP1 | |
| SCHEMBL20631620 | 0.75 | L3MBTL1 (0.49) | MAPTL3MBTL1MAPK1TDP1LMNA | |
| SCHEMBL20631629 | 0.74 | SMN1; SMN2 (0.57) | MEN1KMT2AMAPTL3MBTL1MAPK1 | |
| SCHEMBL20631530 | 0.74 | MAPT (0.47) | MEN1KMT2AMAPTL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019008156-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-10 | — | — | WO | disclosed |