Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPD | P32754 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631379 | 0.91 | MAPT (0.58) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL20630462 | 0.90 | L3MBTL1 (0.50) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL20631620 | 0.83 | L3MBTL1 (0.49) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL20630448 | 0.80 | MAPT (0.59) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL20630953 | 0.78 | MAPT (0.43) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL20610264 | 0.77 | MEN1 (0.44) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL5674481 | 0.77 | MAPT (0.76) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL20630443 | 0.76 | CD274 (0.42) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL20631651 | 0.76 | MAPT (0.54) | L3MBTL1MAPTTDP1MAPK1APP | |
| SCHEMBL20631396 | 0.72 | MAPT (0.58) | L3MBTL1MAPTTDP1MAPK1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019008156-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-10 | — | — | WO | disclosed |