SCHEMBL20612909

SCHEMBL20612909

Cc1cc(F)c(N2CCC(COc3ccc(F)cc3CCO)CC2)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 11/20 0.44
RBP4 P02753 3/20 0.38
TTR P02766 2/20 0.38
DCPS Q96C86 1/20 0.36
HTR2A P28223 2/20 0.36
HTR2C P28335 2/20 0.36
HTR2B P41595 2/20 0.36
MGLL Q99685 1/20 0.36
EGFR P00533 1/20 0.35
FGFR1 P11362 1/20 0.35
FLT1 P17948 1/20 0.35
FLT4 P35916 1/20 0.35
KDR P35968 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20613101 0.94 FFAR4 (0.43) FFAR4RBP4TTRDCPSHTR2A
SCHEMBL25969068 0.88 FFAR4 (0.50) FFAR4RBP4TTR
SCHEMBL20612938 0.85 FFAR4 (0.44) FFAR4RBP4TTR
SCHEMBL25969148 0.84 FFAR4 (0.46) FFAR4RBP4TTRDCPS
SCHEMBL20714057 0.78 FFAR4 (0.43) FFAR4MGLL
SCHEMBL25969024 0.76 FFAR4 (0.41) FFAR4
SCHEMBL20612921 0.75 FFAR4 (0.44) FFAR4MGLL
SCHEMBL25968820 0.75 FFAR4 (0.48) FFAR4
SCHEMBL20612937 0.74 FFAR4 (0.42) FFAR4DCPSEGFRFGFR1FLT1
SCHEMBL25968743 0.73 FFAR4 (0.40) FFAR4DCPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3421454-A1 PIPERIDINE DERIVATIVE Otsuka Pharmaceutical Co., Ltd. (JP) 2019-01-02 EP disclosed