SCHEMBL20612937

SCHEMBL20612937

Cc1cc(F)c(N2CCC(COc3ccc(C)c(N)c3C)CC2)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 13/20 0.42
DCPS Q96C86 2/20 0.40
EGFR P00533 1/20 0.35
FGFR1 P11362 1/20 0.35
FLT1 P17948 1/20 0.35
FLT4 P35916 1/20 0.35
KDR P35968 1/20 0.35
TLR9 Q9NR96 1/20 0.35
TLR8 Q9NR97 1/20 0.35
TLR7 Q9NYK1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25968868 0.89 FFAR4 (0.41) FFAR4DCPS
SCHEMBL25968580 0.78 FFAR4 (0.42) FFAR4
SCHEMBL25968820 0.75 FFAR4 (0.48) FFAR4
SCHEMBL20612907 0.75 FFAR4 (0.41) FFAR4DCPS
SCHEMBL20612909 0.74 FFAR4 (0.44) FFAR4DCPSEGFRFGFR1FLT1
SCHEMBL20613099 0.74 FFAR4 (0.42) FFAR4
SCHEMBL25968983 0.74 FFAR4 (0.43) FFAR4
SCHEMBL25969148 0.73 FFAR4 (0.46) FFAR4DCPS
SCHEMBL20613101 0.73 FFAR4 (0.43) FFAR4DCPS
SCHEMBL25970060 0.73 FFAR4 (0.40) FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3421454-A1 PIPERIDINE DERIVATIVE Otsuka Pharmaceutical Co., Ltd. (JP) 2019-01-02 EP disclosed