SCHEMBL20613616

SCHEMBL20613616

C=C/C=C\C=C/Nc1ccc(-c2ccc(Nc3ccccc3)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.46
ALDH1A1 P00352 9/20 0.43
HSD17B10 Q99714 5/20 0.43
L3MBTL1 Q9Y468 4/20 0.43
TDP1 Q9NUW8 4/20 0.43
ALOX12 P18054 3/20 0.43
TSHR P16473 3/20 0.43
ALOX15 P16050 2/20 0.43
MAPK1 P28482 2/20 0.43
PTGS1 P23219 1/20 0.43
SLC6A2 P23975 1/20 0.43
PTGS2 P35354 1/20 0.43
HTR2B P41595 1/20 0.43
MAPT P10636 3/20 0.38
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
LMNA P02545 2/20 0.38
GAA P10253 1/20 0.38
CYP3A4 P08684 4/20 0.38
HPGD P15428 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10078824 0.88 KMT2A (0.56) KMT2AALDH1A1HSD17B10L3MBTL1TDP1
SCHEMBL13103343 0.88 KMT2A (0.56) KMT2AALDH1A1HSD17B10L3MBTL1TDP1
SCHEMBL29294623 0.80 ALDH1A1 (0.43) KMT2AALDH1A1HSD17B10L3MBTL1TDP1
SCHEMBL27647042 0.80 KMT2A (0.50) KMT2AALDH1A1HSD17B10L3MBTL1TDP1
SCHEMBL100984 0.80 KMT2A (0.50) KMT2AALDH1A1HSD17B10L3MBTL1TDP1
SCHEMBL16500939 0.77 APP (0.43) ALDH1A1HSD17B10L3MBTL1TDP1ALOX12
SCHEMBL23097440 0.75 KMT2A (0.46) KMT2AALDH1A1HSD17B10L3MBTL1TDP1
SCHEMBL19867939 0.74 ALDH1A1 (0.48) KMT2AALDH1A1HSD17B10L3MBTL1TDP1
SCHEMBL67901 0.73 ALDH1A1 (0.81) KMT2AALDH1A1HSD17B10L3MBTL1TDP1
SCHEMBL17965666 0.73 ALDH1A1 (0.81) KMT2AALDH1A1HSD17B10L3MBTL1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3422106-B1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2021-01-20 EP disclosed
EP-3422106-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2019-01-02 EP disclosed