Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 18/20 | 0.68 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.68 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20434274 | 0.81 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL6128041 | 0.80 | TLR8 (0.70) | TLR8TLR7NLRP3 | |
| SCHEMBL6416393 | 0.80 | TLR8 (0.90) | TLR8TLR7 | |
| SCHEMBL11916234 | 0.78 | TLR8 (0.43) | TLR8TLR7PDE10A | |
| SCHEMBL11915815 | 0.76 | PDE10A (0.42) | TLR8TLR7PDE10A | |
| SCHEMBL9287279 | 0.76 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL15764603 | 0.75 | LMNA (0.48) | TLR8TLR7PDE10A | |
| SCHEMBL20614339 | 0.72 | TLR8 (0.39) | TLR8TLR7PDE10A | |
| SCHEMBL7919954 | 0.71 | KDM4E (0.50) | TLR8TLR7 | |
| SCHEMBL11916225 | 0.71 | PDE10A (0.39) | TLR8TLR7NLRP3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322523-B1 | Process for the preparation of Pyridopyrimidinone Inhibitors of PI3Kalpha | EXELIXIS INC (US) | 2019-01-02 | — | — | EP | disclosed |