Sugi Predict

Sugi Predict / Compounds / SCHEMBL20623896

SCHEMBL20623896

SCHEMBL20623896

CC(O)(CC(=O)Nc1nc2cc(C#N)c(C(F)(F)F)nc2n1C1CCC1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ HIF1A Q16665 1/20 0.37
▸ EGFR P00533 12/20 0.36
▸ MAP3K7 O43318 3/20 0.36
▸ IRAK4 Q9NWZ3 3/20 0.36
▸ IRAK1 P51617 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ ALK Q9UM73 1/20 0.34
▸ ADORA2A P29274 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ RXFP1 Q9HBX9 1/20 0.33
▸ P2RY12 Q9H244 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19277840 1.00 KDM4E (0.37) KDM4EALDH1A1HPGDHIF1AEGFR
SCHEMBL19276202 0.90 KDM4E (0.39) KDM4EALDH1A1HPGDHIF1AEGFR
SCHEMBL19278032 0.89 KDM4E (0.35) KDM4EALDH1A1HPGDHIF1AEGFR
SCHEMBL19278274 0.88 EGFR (0.40) KDM4EALDH1A1HPGDHIF1AEGFR
SCHEMBL20624122 0.88 EGFR (0.40) KDM4EALDH1A1HPGDHIF1AEGFR
SCHEMBL20624469 0.87 EGFR (0.37) EGFRMAP3K7IRAK4IRAK1CYP3A4
SCHEMBL19276243 0.87 EGFR (0.37) EGFRMAP3K7IRAK4IRAK1CYP3A4
SCHEMBL20624117 0.83 KDM4E (0.40) KDM4EALDH1A1HPGDHIF1AEGFR
SCHEMBL19277974 0.83 KDM4E (0.40) KDM4EALDH1A1HPGDHIF1AEGFR
SCHEMBL19277972 0.83 KDM4E (0.40) KDM4EALDH1A1HPGDHIF1AEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2023-01-05 — — US disclosed
US-10851067-B2 Kv7 channel activators compositions and methods of use KNOPP BIOSCIENCES LLC (US) 2020-12-01 — — US disclosed
US-20190284142-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE CHANNEL BIOSCIENCES, LLC 2019-09-19 — — US disclosed
US-20190002464-A1 IMIDAZO[4,5-B]PYRIDIN-2-YL AMIDES AS KV7 CHANNEL ACTIVATORS CHANNEL BIOSCIENCES, LLC 2019-01-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190284142-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 KDM4E 1486/4885ALDH1A1 3093/4885HPGD 4074/4885
US-20230000831-A1 KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE KCNA7, KCNK17, KCNAB1 KDM4E 1486/4885ALDH1A1 3093/4885HPGD 4074/4885
US-20190002464-A1 IMIDAZO[4,5-B]PYRIDIN-2-YL AMIDES AS KV7 CHANNEL ACTIVATORS KCNA7, KCNA2, KCNK17 KDM4E 569/4885ALDH1A1 1531/4885HPGD 2199/4885
US-10851067-B2 Kv7 channel activators compositions and methods of use KCNA7, KCNK17, KCNAB1 KDM4E 1486/4885ALDH1A1 3093/4885HPGD 4074/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.