KCNA2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL10924160	0.70	3/20
SCHEMBL3613537	0.67	3/20
SCHEMBL10998626	0.61	3/20
SCHEMBL1344800	0.89	2/20
SCHEMBL13920855	0.73	2/20
SCHEMBL19346062	0.72	2/20
SCHEMBL9122678	0.71	2/20
SCHEMBL2800519	0.70	2/20
SCHEMBL6802035	0.69	2/20
SCHEMBL3189671	0.67	2/20
Isopimpinellin (SCHEMBL498907)	0.66	2/20
SCHEMBL13801188	0.65	2/20
SCHEMBL13197114	0.64	2/20
Bergaptol (SCHEMBL194016)	0.64	2/20
SCHEMBL20036256	0.63	2/20
SCHEMBL2799113	0.63	2/20
SCHEMBL2799121	0.63	2/20
SCHEMBL2799641	0.63	2/20
SCHEMBL2799643	0.63	2/20
SCHEMBL2800797	0.62	2/20

Clinical trials — most relevant to KCNA2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery	PHASE4	RECRUITING
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease	PHASE4	NOT_YET_RECRUITING
Cortical Excitability Changes Induced by Retigabine: a Transcranial Magnetic Stimulation Study	PHASE3	COMPLETED
Mutation-specific Therapy for the Long QT Syndrome	PHASE2	COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients	PHASE2	COMPLETED
4-Aminopyridine in Episodic Ataxia Type 2	PHASE2	WITHDRAWN
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy	PHASE1/PHASE2	RECRUITING
Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss	PHASE2	COMPLETED
Sandostatine® LP and Hyperinsulinism	PHASE2	COMPLETED
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK	PHASE1	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy	nan	UNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
Characteristics of Episodic Ataxia Syndrome	nan	COMPLETED
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats	nan	COMPLETED
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats	nan	COMPLETED
Characteristics of Andersen-Tawil Syndrome	nan	COMPLETED
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia	nan	UNKNOWN
Post-stroke Epilepsy: Primary Prophylaxis Study	nan	UNKNOWN
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	nan	UNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients	nan	UNKNOWN
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
The Use of Antiarrhythmic Drugs in Pediatrics	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a KCNA2 binder may also engage these)

Protein	Name	Similarity
P63141	—	1.000	P63141 →
P63142	—	1.000	P63142 →
P22739	—	1.000	P22739 →
Q28293	—	1.000	Q28293 →
P16388	—	1.000	P16388 →
Q09081	—	1.000	Q09081 →
Q9I830	—	1.000	Q9I830 →
Q16322	—	1.000	Q16322 →
KCNA1	Potassium voltage-gated channel subfamily A member 1	1.000	landscape →
P16390	—	1.000	P16390 →
Q7T199	—	1.000	Q7T199 →
B2RQA1	—	1.000	B2RQA1 →
P10499	—	1.000	P10499 →
P15384	—	0.999	P15384 →
Q9ULS6	—	0.999	Q9ULS6 →
Q9I829	—	0.998	Q9I829 →
P17659	—	0.996	P17659 →
P25122	—	0.995	P25122 →
Q9XXD1	—	0.995	Q9XXD1 →
KCNA6	Potassium voltage-gated channel subfamily A member 6	0.995	landscape →
Q9TT17	—	0.995	Q9TT17 →
P19024	—	0.993	P19024 →
Q61762	—	0.993	Q61762 →
Q61423	—	0.993	Q61423 →
P15385	—	0.993	P15385 →
P15388	—	0.992	P15388 →
Q9BQ31	—	0.991	Q9BQ31 →
Q7TSH7	—	0.991	Q7TSH7 →
Q28527	—	0.990	Q28527 →
Q8I4B0	—	0.990	Q8I4B0 →