Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | MTOR | P42345 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.65 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.65 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CDA | P32320 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | HBB | P68871 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20967857 | 1.00 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL14946394 | 1.00 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL20459954 | 1.00 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL453448 | 1.00 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL6397305 | 1.00 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL14929347 | 1.00 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL453447 | 1.00 | LMNA (0.65) | LMNAMTORTHRBMDM2NCOA1 | |
| Phosphoric Acid SCHEMBL15668496 | 0.96 | LMNA (0.60) | LMNAMTORTHRBMDM2NCOA1 | |
| Cytidine SCHEMBL15054404 | 0.94 | LMNA (0.77) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL27056643 | 0.92 | LMNA (0.55) | LMNAMTORTHRBMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424510-A1 | PREPARATION OF INTERMEDIATES USEFUL IN THE SYNTHESIS OF 2'-CYANO-2'-DEOXY-N4-PALMITOYL-1-BETA-D-ARABINOFURANOSYLCYTOSINE | Cyclacel Limited (GB) | 2019-01-09 | — | — | EP | disclosed |