Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 4/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17550339 | 1.00 | MMP9 (0.33) | MMP9CA2CA12CA1CA7 | |
| SCHEMBL17542346 | 1.00 | MMP9 (0.33) | MMP9CA2CA12CA1CA7 | |
| SCHEMBL20637970 | 1.00 | MMP9 (0.33) | MMP9CA2CA12CA1CA7 | |
| SCHEMBL17542456 | 1.00 | MMP9 (0.33) | MMP9CA2CA12CA1CA7 | |
| SCHEMBL17542216 | 1.00 | MMP9 (0.33) | MMP9CA2CA12CA1CA7 | |
| SCHEMBL20630495 | 0.89 | CA2 (0.36) | CA2 | |
| SCHEMBL20637972 | 0.89 | CA2 (0.36) | CA2 | |
| SCHEMBL17542451 | 0.89 | CA2 (0.36) | CA2 | |
| SCHEMBL17542144 | 0.89 | CA2 (0.36) | CA2 | |
| SCHEMBL17550327 | 0.89 | CA2 (0.36) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424931-A2 | TETRAHYDRONAPHTHALENE DERIVATIVES THAT INHIBIT MCL-1 PROTEIN | Amgen, Inc (US) | 2019-01-09 | — | — | EP | disclosed |