Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ATF4 | P18848 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20610459 | 0.81 | ATF4 (0.59) | KMT2AMEN1MAPTLMNAATF4 | |
| SCHEMBL12629118 | 0.80 | LMNA (0.72) | KMT2AMEN1L3MBTL1LMNAATF4 | |
| SCHEMBL17658518 | 0.80 | LMNA (0.72) | KMT2AMEN1L3MBTL1LMNAATF4 | |
| SCHEMBL19538657 | 0.77 | KMT2A (0.72) | KMT2AMEN1L3MBTL1LMNAATF4 | |
| SCHEMBL3456287 | 0.76 | KMT2A (0.73) | KMT2AMEN1L3MBTL1LMNAHPGD | |
| SCHEMBL23383772 | 0.75 | HDAC1 (0.55) | KMT2AMEN1POLBMAPTLMNA | |
| SCHEMBL17658585 | 0.74 | ATF4 (0.82) | KMT2ALMNAATF4 | |
| SCHEMBL17658644 | 0.74 | ATF4 (0.82) | KMT2ALMNAATF4 | |
| SCHEMBL19134248 | 0.74 | LMNA (0.63) | KMT2AMEN1L3MBTL1LMNAATF4 | |
| SCHEMBL17658492 | 0.74 | ATF4 (0.86) | KMT2AMAPTL3MBTL1LMNAATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019008506-A1 | N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-10 | — | — | WO | disclosed |