Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20633408 | 0.85 | CYP11B2 (0.35) | LRRK2 | |
| SCHEMBL20631699 | 0.83 | CYP11B2 (0.35) | LRRK2PRKDCATR | |
| SCHEMBL20632289 | 0.82 | CYP1A2 (0.34) | HTR2AHTR2C | |
| SCHEMBL20632736 | 0.82 | CDK5 (0.33) | HTR2AHTR2CLRRK2PRKDCATM | |
| SCHEMBL20632237 | 0.80 | CDK5 (0.33) | LRRK2 | |
| SCHEMBL20632592 | 0.80 | CYP1A2 (0.38) | HTR2AHTR2CATR | |
| SCHEMBL20631934 | 0.79 | KDM4E (0.35) | ACP1LRRK2 | |
| SCHEMBL20633147 | 0.79 | CDK5 (0.33) | LRRK2 | |
| SCHEMBL20631659 | 0.79 | GRIN1 (0.32) | HTR2AHTR2C | |
| SCHEMBL20632618 | 0.79 | CYP11B2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |