Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632665 | 0.92 | NPY2R (0.36) | — | |
| SCHEMBL16776287 | 0.89 | ABL1 (0.38) | ABL1GSK3BDYRK1ACYP3A4CYP2D6 | |
| SCHEMBL20632516 | 0.86 | PRMT5 (0.36) | DYRK1ACLK2 | |
| SCHEMBL20632764 | 0.86 | GSK3B (0.36) | ABL1AKT1GSK3BDYRK1ACYP3A4 | |
| SCHEMBL20632281 | 0.86 | CHRM4 (0.35) | ABL1AKT1GSK3BDYRK1ACYP3A4 | |
| SCHEMBL20632299 | 0.86 | GSK3B (0.35) | ABL1AKT1GSK3BDYRK1ACYP3A4 | |
| SCHEMBL20633318 | 0.85 | CLK2 (0.33) | ABL1CLK2 | |
| SCHEMBL20631692 | 0.84 | SLC27A1 (0.36) | ABL1AKT1GSK3BDYRK1ACYP3A4 | |
| SCHEMBL17618747 | 0.83 | ABL1 (0.36) | ABL1GSK3BDYRK1ACLK2 | |
| SCHEMBL16776268 | 0.83 | PRMT5 (0.35) | ABL1GSK3BDYRK1ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |