Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365427 | 0.91 | HDAC2 (0.42) | LRRK2MAP4K1USP30PRKCQHSD11B1 | |
| SCHEMBL17618515 | 0.91 | HDAC2 (0.42) | LRRK2MAP4K1USP30PRKCQHSD11B1 | |
| SCHEMBL20632191 | 0.89 | USP30 (0.41) | LRRK2MAP4K1USP30PRKCQJAK2 | |
| SCHEMBL17618441 | 0.87 | HDAC2 (0.42) | LRRK2USP30HSD11B1HDAC2 | |
| SCHEMBL20633001 | 0.86 | ITK (0.34) | LRRK2MAP4K1 | |
| SCHEMBL20631815 | 0.86 | ITK (0.34) | LRRK2MAP4K1 | |
| SCHEMBL20632386 | 0.86 | ITK (0.34) | LRRK2MAP4K1 | |
| SCHEMBL19706087 | 0.85 | HDAC2 (0.42) | LRRK2MAP4K1USP30HSD11B1HDAC2 | |
| SCHEMBL19670363 | 0.84 | ROCK2 (0.37) | JAK2 | |
| SCHEMBL20631740 | 0.84 | LRRK2 (0.38) | LRRK2MAP4K1PRKCQHSD11B1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |